Liporase Hyaluronidase
What is it?
Liporase is a highly effective hyaluronidase enzyme solution developed by Daehan New Pharm Co., Ltd., South Korea. It is specifically designed to dissolve hyaluronic acid (HA) dermal fillers that have been overfilled, unevenly distributed, or incorrectly placed, as well as to address vascular complications resulting from accidental injection into blood vessels. Additionally, Liporase can enhance the effects of fat-dissolving injections by promoting the absorption of fat cells.
Composition
- Active Ingredient: Hyaluronidase 1,500 IU
- Form: Lyophilized powder
- Packaging: 10 vials per box, each containing 1.0 ml of lyophilized powder
- Manufacturer: Daehan New Pharm Co., Ltd., South Korea
Mechanism of Action
Hyaluronidase is an enzyme that catalyzes the hydrolysis of hyaluronic acid by breaking down its glycosidic bonds. This process allows for the rapid dispersion and reabsorption of HA fillers, effectively reversing their effects. Liporase’s formulation ensures a high concentration of active enzyme, providing efficient and targeted breakdown of HA-based dermal fillers.
Key Benefits
- Rapid Action: Visible effects can be observed within 24–48 hours after injection
- High Efficacy: Achieves up to 90% elimination of unwanted HA fillers
- Safe and Selective: Specifically targets synthetic HA without affecting the body’s natural hyaluronic acid
- Versatile Applications: Suitable for correcting overfilled or misplaced fillers and enhancing fat-dissolving treatments
Clinical Applications
- Correction of HA Fillers: Dissolves overfilled, unevenly distributed, or incorrectly placed HA dermal fillers
- Emergency Use: Addresses vascular complications resulting from accidental injection into blood vessels
- Enhancement of Lipolysis: Boosts the effectiveness of fat-dissolving injections by facilitating the absorption of fat cells
Considerations
- Professional Use Only: Liporase should be administered by qualified medical professionals trained in aesthetic procedures
- Allergic Reactions: Perform a patch test prior to use to ensure no allergic reactions occur
- Storage: Store unopened vials in a cool, dry place. Once reconstituted, use the solution promptly
Liporase provides a reliable and precise solution for the correction and adjustment of HA dermal fillers.


